NEM Brand Eggshell Membrane Effective in the Treatment of Pain and Stiffness Associated with Osteoarthritis of the Knee in an Italian Study Population

A single-center, open-label clinical study was conducted to evaluate the efficacy and safety of NEM as a natural treatment for pain and stiffness associated with osteoarthritis of knee in an Italian population. NEM brand eggshell membrane is a unique dietary supplement that contains naturally occurring glycosaminoglycans and protein essential for maintaining healthy joints and connective tissues. Twenty-five subjects received oral NEM, 500 mg once daily for four weeks. The primary outcome measure was to evaluate the mean effectiveness of NEM in relieving general pain associated with moderate osteoarthritis of the knee at 10 and 30 days utilizing a 10-question, abbreviated questionnaire based on the WOMAO osteoarthritis questionnaire. Supplementation with NEM produced a significant treatment response from baseline at both 10 days and 30 days for composite pain (40.6% reduction, p<0.001; 64.4% reduction. p<0.001, respectively). There was also a statistically significant concurrent reduction in analgesic use during the 30-day study period. Additionally, a significant treatment response from baseline was also observed for composite stiffness at both 10 days and 30 days (22.2% reduction, p=0.009; 59.7% reduction, p<0.001, respectively) . There were no adverse events or serious adverse events reported during the study and the treatment was reported to be well tolerated by study participants. NEM is an effective and safe natural therapeutic option for treatment of both pain and stiffness associated with osteoarthritis of the knee. Supplementation with NEM, 500 mg taken once daily, significantly reduce both pain and stiffness rapidly (10 days) and this effect continued to improve through 30 days. There was also a meaningful reduction in the amount of analgesic consumed on a weekly basis, which further enhanced patients’ safety.